T he introductory Sections 2 and 3 include eight new chapters on topics ranging from the future of clinical trials, the evaluation and provision of effective medicines, to health promotion. It differs most blatantly from previous editions in having the gift of colour throughout and the inclusion of ‘Essentials’ (mostly written and all edited by John Firth) that summarize the main points of each chapter. T he Fifth edition has been rigorously revised and updated. T he popular term, ‘translational medicine’, reflects the shared optimism of many research agencies. Spectacular advances have been made at the most fundamental level and these continue to inspire our belief that improved prevention, diagnosis and treatment of disease will eventually relieve suffering. T here is much to celebrate, and-with many new contributors-we have sought throughout the book to reflect the revolutionary effects of discovery in the medical sciences on clinical practice. Publication of this new edition of the Oxford Textbook of Medicine prompts consideration of the precepts and practices of medicine in a world that faces unprecedented challenges.

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